DuoStim It is one of the treatment protocols currently used in assisted reproduction. The DuoStim (Double Stimulation) aims to achieve two OPU to capture a greater number of mature oocytes in the same menstrual cycle.
When it should be indicated?
DuoSTim It is indicated for patients undergoing treatment IVF or fertility preservation with an emergency, for example egg freezing by oncology patients who will carry out treatment with chemotherapy.
These patients need to start with medications inducing ovulation on day 2 of the menstrual cycle to recruit a large number of ovarian follicles. But in some cases, even with high doses of medications have patients who do not have a good answer, where called low responders (or poor answer). In this scenario of patients with low response to stimulation (with production 5 mature eggs) often it turns out to be necessary to perform more than one induction loop for preservation of fertility or IVF.
How is the DuoStim?
No DuoStim The patient performs similar inducing ovarian stimulation in in vitro fertilization, which lasts on average 10-12 dias. After follicular aspiration to capture the mature eggs, it needs to perform a transvaginal ultrasound of the 3rd to 5th day, starting again medications from ovarian stimulation. According to the response and follicular growth averaged 10-12 dias, a new vacuum will be held in the same cycle. The medications that are used in the protocol are defined according to the experience of each professional and individually, for each protocol in assisted reproduction is evaluated after a careful survey and appropriate medical.
What are the advantages and disadvantages of DuoStim?
One of the advantages of the Protocol DuoStim It is to use a single menstrual cycle to perform two recruitment in different phases of the cycle, It is the first in the follicular phase (beginning on the 2nd day of the menstrual cycle) and the second luteal phase (starting between the 3rd – 5Th day after the first OPU), that way the patient gets a greater number of mature eggs in a short period of time, ou historian, no need to wait for a new menstrual cycle to start a new ovarian stimulation protocol, if specified by a specialist.
In contrast, the disadvantages of DuoStim estão: the cost of medications, the availability of time that the patient needs to perform all monitoring correctly and anxiety of the couple for failing to carry out embryo transfer in the same induction cycle, it is important at this time the doctor's guidance regarding the cost versus benefits of the Protocol.